The new study conducted by Oxford university shows that Mixing doses of the Pfizer and AstraZeneca vaccines can generate a strong immune response against Covid 19. The study found that those who are given a dose of AstraZeneca followed by a dose of Pfizer four weeks later generated a better immune response.
Oxford developed the AstraZeneca vaccine, which is used in the U.K. In the U.S., three other Covid 19 vaccines are available: Moderna, Johnson & Johnson and Pfizer-BioNTech.The Oxford study used 830 volunteers, 50 years or older, in the U.K. to test four different vaccine combinations.
The study found that while taking AstraZeneca followed by Pfizer yielded higher antibodies and T-cell responses. It showed that mixing Doses of Pfizer and AstraZeneca regardless of the order resulted in higher antibodies than the standard two-dose AstraZeneca shot. The study also tested the standard vaccine doses and found that the highest antibody response was seen after two doses of Pfizer.Professor Matthew Snape, chief investigator on the trial, said the results point to potentially allowing flexibility in the U.K. and global vaccine roll-out. Snape also added that these results are an invaluable guide to the use of mixed dose schedules. However, the interval of four weeks studied here is shorter than the eight to 12-week schedule most commonly used for the Oxford-AstraZeneca vaccine.
In May, the Com-Cov study revealed that mixing vaccines resulted in more frequent mild to moderate reactions, but these reactions were short-lived. Researchers are also testing Covid 19 vaccine Moderna and Novavax vaccines in a new study. Six new arms of the trial recruited approximately 175 candidates each, adding a further 1,070 people to the program.